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Welcome to the ESSIC website

ESSIC uses the name bladder pain syndrome (BPS) instead of interstitial cystitis (IC) and/or painful bladder syndrome (PBS): click here for more details
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Go to the ESSIC member page (user name and password required)    



Preliminary information: the next ESSIC Annual Meeting wild possibly be held in Rome (Italy) in December 2018.

<click here> to go to the Defoe home page for further information.


  • Review of the ESSIC Annual Meeting 13-15 June 2014, Philadelphia (USA)
    Review of the ESSIC Annual Meeting 2014, 13-15 June, Geary Hall, Hahnemann Hospital, Drexel University, Philadelphia, USA
    by Jane Meijlink, International Painful Bladder Foundation (IPBF). Click here

  • Proceedings of the Joint Meeting of ESSIC and ICICJ, Kyoto (Japan) 21-23 March 2013
    Proceedings of the 3rd International Consultation on Interstitial Cystitis, Japan (ICICJ) and the 
    International Society for the Study of Bladder Pain Syndrome (ESSIC) Joint Meeting, held 21–23 March 2013, Kyoto, Japan, have been published in a special issue of the International Journal of Urology, April 2014, Volume 21, Supplement S1 with free access. Click here
  • Review of the ESSIC Annual Meeting 21-23 March 2013, Kyoto (Japan)
    The ESSIC Annual Meeting 2013 was held in Kyoto, Japan, 21-23 March 2013. It was a joint meeting with the Japanese 3rd ICICJ.
    Jane Meijlink, chair of the IPBF (International Painful Bladder Foundation) has made an excellent review of the meeting that can be accessed via the IPBF homepage.
Wennevik GE, Meijlink JM, Hanno P, Nordling J. The role of glomerulations in Bladder Pain Syndrome - A review.
J Urol 2015 Aug 26. pii: S0022-5347(15)04683-2. doi: 10.1016/j.juro.2015.06.112. [Epub ahead of print]. PMID: 26318984.
The full paper is available for ESSIC members via the ESSIC member page.

PURPOSE: Glomerulations as a diagnostic marker for bladder pain syndrome/interstitial cystitis (BPS/IC) was first popularized by Messing & Stamey in 1978. Later this was included in the NIDDK criteria for research and consequently used by many urologists as a default diagnostic criterion. Today, the connection between glomerulations and BPS/IC is much debated, as research has found glomerulations in asymptomatic populations. This paper systematically looks at the available research to see if there is valid data to support the use of glomerulations as a marker for BPS/IC.
MATERIALS AND METHODS: A systematic literature search of the PubMed database in March 2014 using the search term "Cystitis, Interstitial/diagnosis" [MAJR] OR (glomerulations OR glomerulation OR bladder petechiae) was performed and yielded 463 hits, and an Embase search using the search term "glomerulations" yielded 110 references of which 68 were duplicates. Relevant articles were reviewed and included in the study. Bibliographies of reviews, articles and status reports were examined to find studies not included in the search. In total twenty-nine publications were included in this review.
RESULTS: There is no consistent relationship between glomerulations and the diagnosis of BPS/IC. In the reviewed studies, we found evidence of the grade of glomerulations changing over time. Furthermore, many studies showed no link between the severity of symptoms and the number of glomerulations. There were studies that found glomerulations in healthy asymptomatic populations as well as in symptomatic populations with another primary diagnosis. One study found no glomerulations in an asymptomatic population.
CONCLUSIONS: From the reviewed literature, we found no convincing evidence that glomerulations should be included in diagnosis or phenotyping of BPS/IC. It does not correlate with symptoms and is found in patients without BPS/IC.



Bladder Pain Syndrome: A Guide for Clinicians

Jørgen Nordling, Jean-Jacques Wyndaele, Joop P van de Merwe, Pierre Bouchelouche, Mauro Cervigni, Magnus Fall (Editors.)
2013, 2013, XV, 365 p. 76 illus., 68 in color.
Ebook: € 159,99
Hardcover € 181,85 
ISBN 978-1-4419-6929-3

Click here for the Content of the book
Publisher: www.springer.com/medicine/urology/book/978-1-4419-6928-6

• Bladder Pain/ Interstitial Cystitis Symptom Score (BPIC-SS)            
The Bladder Pain/Interstitial Cystitis Symptom Score (BPIC-SS)
The Bladder Pain/ Interstitial Cystitis Symptom Score (BPIC-SS) is a reliable, valid, and appropriate questionnaire, based on patient-reported symptoms, to select BPS/interstitial cystitis patients for clinical trials. Copies of the BPIC-SS, including translations, will be available free of charge (see the full paper).

Humphrey L, Arbuckle R, Moldwin R, Nordling J, van de Merwe JP, Meunier J, Crook T, Abraham L. The bladder pain/interstitial cystitis symptom score: development, validation, and identification of a cut score. Eur Urol 2012;61:271-9.

Click here for a review copy of the BPIC-SS (for further details: see the ESSIC members page) or go to the Pfizer Patient-Reported Outcomes webpage
• Guidelines              
European Association of Urology (EAU) Guidelines on Chronic Pelvic Pain (2014), for the section on BPS click here.              

The American Urological Association (AUA) announced its first guideline for the condition the AUA now refers to as interstitial cystitis/bladder pain syndrome (IC/BPS).
- AUA 2011 Guidelines
- Revised AUA Guidelines on Diagnosis and Treatment of IC/BPS 2014
- AUA Treatment Algorithm 2014

• Dissertations            

Bladder pain syndrome/interstitial cystitis. Studies on classic BPS/IC, ESSIC type 3C, with special reference to the role of nitric oxide.
PhD thesis 2012 of Ýr Logadóttir. Sahlgrenska Academy, University of Göteborg (Sweden)

Bladder Pain Syndrome. Symptoms, quality of life, treatment intensity, clinical and pathological findings, and their correlations.
PhD thesis 2010 of Benedikte Richter. Faculty of Health Sciences. University of Copenhagen (Denmark)


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